Journals › Sri Lanka Journal of Psychiatry
Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy
Sri Lanka Journal of Psychiatry 11(2): 38–39 · 2020
https://doi.org/10.4038/sljpsyc.v11i2.8259
Abstract
Clozapine is prescribed for resistant schizophrenia. It is usually associated with weight gain. There have been only a few reports of weight loss associated with clozapine treatment and we report two patients from Sri Lanka. The first patient lost 27% of bodyweight on clozapine while the second lost 17%. Both were clinically stable on clozapine, with marked reduction of psychotic symptoms. Adding risperidone helped to regain the lost weight in the described patients.
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